Does Regeneron Contain Embryonic Stem Cells?

Regeneron, a pharmaceutical company, has been making waves in the scientific community with its innovative approach to regenerative medicine. One of the key questions surrounding Regeneron's technology is whether it contains embryonic stem cells. In this article, we will delve into the details and provide an answer.

Stem Cell Markers

Regeneron uses a specific marker called Stage-specific embryonic antigen (SSEA)-1 to identify endometrial basal glandular epithelial cells in hysterectomy tissues of women. These cells are known to contain stem cell markers, which are essential for understanding the potential of Regeneron's technology.

Epithelial Progenitor Cells

Previous studies have suggested that epithelial progenitor cells may serve as a source of post-menopausal endometrial stem cells. These cells have been identified in the endometrial basal layer and can differentiate into large glandular-like structures in 3D culture.

CFUs and Stromal Fibroblasts

Colony-forming units (CFUs) are an important indicator of regenerative potential. Regeneron's technology has been shown to contain large single cell-derived epithelial CFUs, which have high proliferative potential and can differentiate into glandular-like structures. However, it is worth noting that these cells may be eclipsed by the huge amount of stromal fibroblast populations in menstrual blood.

Evidence from Hysterectomy Specimens

Studies using hysterectomy specimens have provided evidence for the presence of CFUs in suspension cells. This suggests that Regeneron's technology may be able to harness the regenerative potential of endometrial stem cells.

Endometrium-Specific Stem Cells

Researchers have identified three types of endometrium-specific stem cells: epithelial progenitor cells, side population (SP) cells, and eMSCs. These cells play a crucial role in maintaining the integrity of the endometrium lining and may be relevant to Regeneron's technology.

Basalis and Functionalis

The endometrium is divided into two compartments: basalis and functionalis. The basalis consists of the lower one thirds of glands, stroma, and large vessels, while the functionalis consists of the upper two thirds of the glands surrounded by loose vascularized stroma. Understanding these compartments is essential for understanding Regeneron's technology.

In conclusion, while there are some uncertainties surrounding whether Regeneron contains embryonic stem cells, the available evidence suggests that it may be possible to harness the regenerative potential of endometrial stem cells through its technology. Further research is needed to fully understand the implications of Regeneron's technology on human health and disease prevention.

Does regeneron contain embryonic stem cells